The size of the leading follicles in conjunction with serum hormone levels are used to determine the optimal time for giving the HCG trigger for IVF. Follicles have traditionally been measured manually with two-dimensional (2D) ultrasound by calculating the mean of the 2 largest follicle diameters.

Because follicles are often quite irregular in shape, measuring the follicles in the traditional fashion can result in significant inaccuracy. Another issue with manual measurements is that it is time consuming for the staff and the patients.

General Electric (GE) has software (Automated Volume Count, SonoAVC) for three-dimensional (3D) ultrasound machines that can identify follicles and automatically calculate their volumes. It then converts the measured volumes to diameters by using the sphere formula.x`

It is possible that this technology could give more accurate follicle measurements and also could increase the efficiency of the ultrasound monitoring process.

Materials and Methods :

    • This study was a retrospective review of ultrasound follicle measurements during ovarian stimulation for IVF and the outcome parameters for those cycles.
    • The purpose was to study effectiveness and efficiency of 3D ultrasound assessment of follicle size during ovarian stimulation for IVF using Nucleus fertility Research and Gynaec Centre.
    • Clinical pregnancy rates, total number of eggs retrieved, mature eggs retrieved and percentage of mature eggs were compared in 2 groups.
    • Group 1 included all women using own eggs under age 35 having egg retrievals during the 9 month period of October 2007 through June 2008. Almost all patients in Group 1 had follicles measured manually (2D) with a GE Voluson 730 ProV machine by averaging 2 diameters.
    • Group 2 included all women using own eggs under age 35 that had egg retrievals in the next 9 months (July 2008 through March 2009). Almost all of the patients in Group 2 had follicles measured using the SonoAVC software (3D) and a GE Voluson E8 Expert machine.